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The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Nutrition 2008;24(4):305-313. View abstract. Li G, Fu J, Zhao Y, Ji K, Luan T, Zang B. Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Inflammation. 2015;38(2):510–9. doi:10.1007/s10753-014-9957-3.
Ranking the best alpha-lipoic acid supplements of 2022 Ranking the best alpha-lipoic acid supplements of 2022
Though alpha-lipoic acid has been shown to aid blood sugar control, it’s not considered a complete treatment for diabetes. If you have diabetes and want to try alpha-lipoic acid, it’s best to first talk with your doctor, as it may interact with your medications. Summary What’s more, a review of studies found that taking an alpha-lipoic acid supplement lowered triglyceride and LDL (bad) cholesterol levels in adults with metabolic disease ( 13). SummaryWhat are the most important factors to look for when buying an ALA supplement? Third-party testing guarantees the purity of the capsules and means you don’t have to worry about the supplements’ benefits being fabricated by the manufacturer. When was alpha-lipoic acid first discovered? It was first discovered in 1937. Studies of potato juice found that certain bacteria relied on the juice to reproduce, which in turn led to the discovery of ALA. It wasn’t used in a clinical sense until 1959 in Germany when doctors used it to treat poisoning from death cap mushrooms. Available evidence suggests that between 300 and 600 mg of ALA is suitable for daily consumption. If you use alpha-lipoic acid exclusively for diabetic reasons, you might benefit from taking between 600 and 1200 mg each day. Depending on how many milligrams are contained within each supplement capsule, this may be 1 or 2 pills. Tarnopolsky, M. A. and Raha, S. Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med Sci Sports Exerc. 2005;37(12):2086-2093. View abstract. Alpha-lipoic acid can help with Vitiligo. Taking a product that has a combination of vitamin E, vitamin C, and alpha-lipoic acid along with daily light therapy for about 8 months can improve skin coloration among people suffering from Vitiligo and have patchy skin. Side Effects
Alpha Lipoic Acid Benefits | New Health Advisor Alpha Lipoic Acid Benefits | New Health Advisor
While ALA is considered safe, there are no guidelines directing its use. Most oral supplements are sold in capsule or tablet formulations ranging from 100 milligrams to 600 milligrams. A dose of 600 milligrams to 1,200 milligrams daily appears the most common in studies. This is typically divided into three equal doses each day. Breast-feeding: There isn't enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use. Alpha-lipoic acid may play a role in weight loss. One of the main benefits of taking alpha-lipoic acid is the weight loss tendency it has. Taking ALA daily at doses of 1800mg for 20 weeks can help in the reduction of weight. Chaparro, L. E., Wiffen, P. J., Moore, R. A., and Gilron, I. Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database.Syst.Rev. 2012;7:CD008943. View abstract.
StatPearls [Internet].
Moreover, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been shown to improve recovery outcomes ( 28). When alpha-lipoic acid is taken orally, it can improve symptoms such as numbness, pain, and burning in the arms and legs of people who have diabetes. The symptoms need a period of about 3-5 weeks to show signs of improvement ( 2 ).
ALPHA-LIPOIC ACID - Uses, Side Effects, and More - WebMD
High levels of fats called triglycerides in the blood (hypertriglyceridemia). Taking alpha-lipoic acid by mouth doesn't seem to reduce triglyceride levels in most people. Huang H, Zhu KS Wang P Qu JC Ji XF & Song M. The effects of lipoic acid and prostaglandin E1 on diabetic peripheral neuropathy. Chinese Journal of Clinical Health 2008;11:29-30. Esposito C, Ugo Garzarella E, Santarcangelo C, et al. Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: a monocentric, randomized, double-blind, placebo-controlled clinical trial. Biomedicine & Pharmacotherapy. 2021;144:112308. doi:10.1016/j.biopha.2021.112308Fu Y. Effects of alpha lipoic acid and mecobalamin on diabetic peripheral neuropathy. Chinese Journal of Practical Internal Medicine. 2008;28:81-83. Both human and lab studies suggest that alpha-lipoic acid slows the progression of Alzheimer’s disease by neutralizing free radicals and suppressing inflammation ( 24, 25, 26). It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy ( 1).
Alpha-Lipoic Acid (ALA) as a supplementation for weight loss Alpha-Lipoic Acid (ALA) as a supplementation for weight loss
Lee, S. H., Kim, M. J., Kim, B. J., Kim, S. R., Chun, S., Ryu, J. S., Kim, G. S., Lee, M. C., Koh, J. M., and Chung, S. J. Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson's disease. Mov Disord. 2-15-2010;25(3):332-340. View abstract. Byun, C. H., Koh, J. M., Kim, D. K., Park, S. I., Lee, K. U., and Kim, G. S. alpha-Lipoic Acid Inhibits TNF-alpha-Induced Apoptosis in Human Bone Marrow Stromal Cells. J Bone Miner.Res 2005;20(7):1125-1135. View abstract. Alpha-lipoic acid may provide health benefits, including supporting weight loss and lowering blood sugar levels. You can get it through food and supplements with minimal side effects.
Ultimately, there’s no right answer for everyone, so we included options between 60 and 240 to be safe. Doctor’s best provides a good short term dose of ALA for specific needs, like pre-diabetic treatment or relief from various painful conditions. 8. Jarrow Formulas Alpha Lipoic Supplements Lu YH. Observation of -lipoic acid and ligutrazine curing diabetic peripheral neuropathy. Medical Recapitulate 2009;2:62. All of the top choices above, like Nutricost , have capsules that are third-party tested for both purity and potency. That means that organizations not connected to the manufacturer (and who thus have nothing to lose if the pill doesn’t work) tested the capsules themselves to make sure that their ALA content was legitimate and that the capsules provided real benefits to their users. Always consult your physician before taking alpha-lipoic acid or any other kind of supplement to keep yourself away from any possible side effects. Recommend Dosage
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